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Year Number of Results
2007 2
2008 1
2010 1
2012 1
2013 1
2014 1
2015 1
2016 1
2017 3
2018 1
2021 1
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2023 2
2024 1

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15 results

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Page 1
Identification, functional characterization and expression pattern of interferon-gamma (IFN-gamma) and interferon-gamma receptor 1 (IFNGR1) in Nibea albiflora.
Liu Y, Li K, Wenren M, Cheng W, Zhou X, Xu D, Chi C, Lü Z, Liu H. Liu Y, et al. Fish Shellfish Immunol. 2024 Jan;144:109274. doi: 10.1016/j.fsi.2023.109274. Epub 2023 Dec 9. Fish Shellfish Immunol. 2024. PMID: 38072135
Interferon-gamma (IFN-gamma) is an inflammatory cytokine that plays a crucial role in regulating both innate and cell-mediated immune responses by binding to a receptor complex made up of IFNGR1 and IFNGR2. In this study, the complete cDNA of IFN-gamma and IFNGR1 fr …
Interferon-gamma (IFN-gamma) is an inflammatory cytokine that plays a crucial role in regulating both innate and cell-mediated immune respon …
Vaccine Protection of Mice With Primary Immunodeficiencies Against Disseminated Coccidioidomycosis.
Powell DA, Hsu AP, Butkiewicz CD, Trinh HT, Frelinger JA, Holland SM, Galgiani JN, Shubitz LF. Powell DA, et al. Front Cell Infect Microbiol. 2022 Jan 7;11:790488. doi: 10.3389/fcimb.2021.790488. eCollection 2021. Front Cell Infect Microbiol. 2022. PMID: 35071044 Free PMC article.
To determine if vaccination could provide these mice protection, mice with mutations in Stat4, Stat3, Ifngr1, Clec7a (Dectin-1), and Rag-1 (T- and B-cell deficient) knockout (KO) mice were vaccinated with the live, avirulent, deltacps1 vaccine strain and subsequently chall …
To determine if vaccination could provide these mice protection, mice with mutations in Stat4, Stat3, Ifngr1, Clec7a (Dectin-1), and …
Unique Presentations of Burkholderia gladioli Infections in Several Strains of Immunocompromised Mice.
Osborne AJ, Clark SE, Whitcomb T, Devlin P, Lanza M, Atkins HM. Osborne AJ, et al. Comp Med. 2023 Oct 29;73(5):391-397. doi: 10.30802/AALAS-CM-23-000016. Epub 2023 Sep 20. Comp Med. 2023. PMID: 38087404 Free PMC article.
Cg- Rag1 (tm1Mom) Il2rg (tm1Wjl) /SzJ [NRG], B6.129S(Cg)-Stat1 (tm1Dlv)/J [STAT1 (-/-)], and B6.129S7- Ifngr1 (tm1Agt)/J[IFNgammaR (-/-)] housed in a barrier facility developed unusual and seemingly unrelated clinical signs. ...NSG/NRG mice had moderate-markedly enlarged l …
Cg- Rag1 (tm1Mom) Il2rg (tm1Wjl) /SzJ [NRG], B6.129S(Cg)-Stat1 (tm1Dlv)/J [STAT1 (-/-)], and B6.129S7- Ifngr1 (tm1Agt)/J[IFNgammaR (- …
IFNGR1 signaling is associated with adverse pregnancy outcomes during infection with malaria parasites.
Niikura M, Inoue SI, Mineo S, Asahi H, Kobayashi F. Niikura M, et al. PLoS One. 2017 Nov 8;12(11):e0185392. doi: 10.1371/journal.pone.0185392. eCollection 2017. PLoS One. 2017. PMID: 29117241 Free PMC article.
Importantly, we found that fetal mortality in IFNGR1-deficient mice infected with PbNK65L parasites was much less than in infected wild type (WT) mice. Placental pathology was also improved in IFNGR1-deficient mice. In contrast, bioluminescence imaging showed that p …
Importantly, we found that fetal mortality in IFNGR1-deficient mice infected with PbNK65L parasites was much less than in infected wi …
Transcriptomic analysis of spleen infected with infectious salmon anemia virus reveals distinct pattern of viral replication on resistant and susceptible Atlantic salmon (Salmo salar).
Dettleff P, Moen T, Santi N, Martinez V. Dettleff P, et al. Fish Shellfish Immunol. 2017 Feb;61:187-193. doi: 10.1016/j.fsi.2017.01.005. Epub 2017 Jan 4. Fish Shellfish Immunol. 2017. PMID: 28063951
We evaluated the differential expression of both host and ISAv genes in a target organ for the virus, i.e. the spleen. The results showed differential expression of host genes related to response to stress, immune response and protein folding (genes such as; atf3, mhc, mx1 …
We evaluated the differential expression of both host and ISAv genes in a target organ for the virus, i.e. the spleen. The results sh …
Hematopoietic stem cell gene therapy for IFNγR1 deficiency protects mice from mycobacterial infections.
Hetzel M, Mucci A, Blank P, Nguyen AHH, Schiller J, Halle O, Kühnel MP, Billig S, Meineke R, Brand D, Herder V, Baumgärtner W, Bange FC, Goethe R, Jonigk D, Förster R, Gentner B, Casanova JL, Bustamante J, Schambach A, Kalinke U, Lachmann N. Hetzel M, et al. Blood. 2018 Feb 1;131(5):533-545. doi: 10.1182/blood-2017-10-812859. Epub 2017 Dec 12. Blood. 2018. PMID: 29233822 Free article.
Biallelic null mutations in genes encoding interferon gamma receptor 1 or 2 (IFNGR1 or IFNGR2) result in a life-threatening disease phenotype in early childhood. ...Transplantation of genetically corrected HSCs into Ifngammar1(-/-) mice before BCG infection prevented manif …
Biallelic null mutations in genes encoding interferon gamma receptor 1 or 2 (IFNGR1 or IFNGR2) result in a life-threatening disease p …
Genomic structure and characterization of mRNA expression pattern of porcine interferon gamma receptor 1 gene.
Xing F, Jiang C, Liang S, Kang L, Jiang Y. Xing F, et al. Int J Immunogenet. 2010 Dec;37(6):477-85. doi: 10.1111/j.1744-313X.2010.00951.x. Int J Immunogenet. 2010. PMID: 20637044
The mRNA expression of porcine IFNGR1 gene is detected in all tissues examined, with strong expression in spleen and liver tissues and weak expression in cerebrum, cerebellum and uterus tissues, respectively. ...In porcine reproductive and respiratory syndrome virus …
The mRNA expression of porcine IFNGR1 gene is detected in all tissues examined, with strong expression in spleen and liver tis …
Molecular cloning and characterization of chicken interferon-gamma receptor alpha-chain.
Han X, Chen T, Wang M. Han X, et al. J Interferon Cytokine Res. 2008 Jul;28(7):445-54. doi: 10.1089/jir.2007.0135. J Interferon Cytokine Res. 2008. PMID: 18597622
Expression analysis by Northern blot revealed that the chIFNGR-1 was highly expressed in spleen, thymus, peripheral blood lymphocytes (PBLs), lung, cecum tonsil, and liver. ...These * ndings show that the identified chicken cDNA sequence encodes an IFNGR1 homologue, …
Expression analysis by Northern blot revealed that the chIFNGR-1 was highly expressed in spleen, thymus, peripheral blood lymphocytes …
UV and hydrogen peroxide treatment restores changes in innate immunity caused by exposure of fish to reuse water.
Singh A, Havixbeck JJ, Smith MK, Shu Z, Tierney KB, Barreda DR, El-Din MG, Belosevic M. Singh A, et al. Water Res. 2015 Mar 15;71:257-73. doi: 10.1016/j.watres.2015.01.003. Epub 2015 Jan 12. Water Res. 2015. PMID: 25622003
The innate immunity parameters assessed were cytokine (IFNgamma, IL-1beta, IL-10, TNFalpha2), and cytokine receptor (TNFR1, TNFR2, IFNGR1, IFNGR2) gene expression, and phagocytosis of kidney leukocyte subpopulations. ...The acute exposure of fish to reuse water caused sign …
The innate immunity parameters assessed were cytokine (IFNgamma, IL-1beta, IL-10, TNFalpha2), and cytokine receptor (TNFR1, TNFR2, IFNGR1 …
Importance of T cells, gamma interferon, and tumor necrosis factor in immune control of the rapid grower Mycobacterium abscessus in C57BL/6 mice.
Rottman M, Catherinot E, Hochedez P, Emile JF, Casanova JL, Gaillard JL, Soudais C. Rottman M, et al. Infect Immun. 2007 Dec;75(12):5898-907. doi: 10.1128/IAI.00014-07. Epub 2007 Sep 17. Infect Immun. 2007. PMID: 17875636 Free PMC article.
Rag2-/- and Cd3epsilon-/- mice were significantly impaired in the ability to clear M. abscessus from the liver and spleen, and muMT-/- mice were significantly impaired in the ability to clear M. abscessus from the liver, suggesting that infection control was primarily T ce …
Rag2-/- and Cd3epsilon-/- mice were significantly impaired in the ability to clear M. abscessus from the liver and spleen, and muMT-/ …
15 results